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More African nations join International Solar Alliance - The Statesman

Pacific Islands Cancer News (Google) - Mon, 05/22/2017 - 18:27

The Statesman

More African nations join International Solar Alliance
The Statesman
The Pacific island nation of Nauru also submitted its instrument of ratification at an ISA event held on the sidelines of the African Development Bank (AfDB) annual meeting here. This is the first time that India is hosting the AfDB annual meeting ...
India to invest $2 bn for solar projects in AfricaNewsBytes

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Study offers guidance for targeting residual ovarian tumors

MIT Cancer Research RSS - Mon, 05/22/2017 - 17:00

Most women diagnosed with ovarian cancer undergo surgery to remove as many of the tumors as possible. However, it is usually impossible to eliminate all of the cancer cells because they have spread throughout the abdomen. Surgery is therefore followed by 18 weeks of chemotherapy.

Delivering chemotherapy drugs directly to the abdomen through a catheter offers better results than other methods, but this regimen suffers from significant complications, and many patients are unable to complete it.

MIT researchers who are working on an implantable device that could make intraperitoneal chemotherapy more bearable have published a new study that offers insight into how to improve chemotherapy strategies for ovarian cancer, and how to determine which patients would be most likely to benefit from this device.

“As we entered into this project, our question was how do we get the same beneficial outcomes and reduce all the side effects?” says Michael Cima, the David H. Koch Professor of Engineering in the Department of Materials Science and Engineering, a member of MIT’s Koch Institute for Integrative Cancer Research, and the senior author of the study.

The findings suggest that the outcome of initial surgery plays a key role in the effectiveness of subsequent intraperitoneal chemotherapy. Cisplatin, one of the most commonly used drugs, effectively treats very tiny tumor cell clusters when it is delivered continuously or as a single large dose. But the researchers found that for larger tumor cell clusters, continuous delivery of cisplatin, at higher doses than are tolerable with the current periodic chemotherapy method, was more effective. The device they are developing would make delivery of such higher, continuous doses possible.

Laura Tanenbaum, who recently received her PhD from the Harvard-MIT Program in Health Sciences and Technology (HST), and HST PhD student Aikaterini Mantzavinou are the lead authors of the paper, which appears in the journal Gynecologic Oncology. Other authors are HST PhD student Kriti Subramanyam and Massachusetts General Hospital gynecologic oncologist Marcela del Carmen.

Targeting residual tumors

Ovarian cancer is usually not detected until the cancer has reached an advanced stage, with metastases covering organs throughout the peritoneal cavity, including the liver, bladder, and intestines. After surgery, known as “tumor debulking,” patients receive two types of chemotherapy to treat tumors left behind: intravenous delivery of paclitaxel and intravenous or intraperitoneal delivery of a platinum drug such as cisplatin.

Intraperitoneal chemotherapy is pumped directly into the abdomen through a catheter every three weeks for a total of six cycles. This allows cisplatin to come in direct contact with the residual tumors, which has been shown to be more effective than intravenous delivery but is not tolerable for many patients. “It’s painful and the catheter can be a site of local infections,” Cima says.

Several years ago, Cima and colleagues set out to develop an implantable device that could deliver cisplatin into the abdomen without all of the side effects produced by the catheter and the large, repeated cisplatin doses. As this project was neither traditional clinical research nor fundamental scientific research, enabling support came from the Koch Institute’s Frontier Research Program and then later on, the Bridge Project, a partnership between MIT’s Koch Institute and the Dana-Farber/Harvard Cancer Center.

Their device is made of a drug-loaded polymer that could be inserted at the beginning of treatment and remain in place for the full treatment course, then removed with minimally invasive surgery. The researchers have tested proof-of-concept devices in mice and are now developing a version that could be tested in humans, though more animal studies are needed before human trials can begin.

In their new study, the researchers set out to investigate how the size of the residual tumors would affect their response to continuous, low-dose cisplatin delivery. They believed that size would play some role because once tumors reach a certain size, the drug may not be able to penetrate all the way into the inner core of the tumors.

To test this hypothesis, the researchers grew spherical ovarian cancer cell clusters 100 or 200 microns in diameter in a lab dish and exposed them to varying doses of cisplatin. Continuous, low-dose cisplatin delivery, similar to what tumors would receive from an implanted device, was as effective against 100-micron tumor spheroids as a single high dose, similar to that delivered by a catheter.

However, by increasing the continuous cisplatin dose, the researchers found that they could treat the larger 200-micron spheroids more effectively than they could with the single high dose. This increased dose could be delivered using an implantable device, but it would not be tolerable for patients if given through an abdominal catheter.

Better treatment strategies

Cima believes that the findings may also help to explain some of the preliminary results of a recent, large clinical trial in which doctors found that intraperitoneal cisplatin delivery was no more effective than intravenous chemotherapy alone. This contradicted previous findings from smaller studies, indicating that cisplatin delivery by catheter improved patient survival.

In the newer trial, conducted at about 500 treatment centers, surgeons admitted patients to the study based on size estimates of the tumors remaining after surgery. However, Cima says, this subjective evaluation may have resulted in patients entering the study whose tumors were too large to be helped by the current intraperitoneal therapy.

This points to the importance of both developing a good method for screening patients before future trials begin, to make sure they are likely to benefit from the treatment, and devising new strategies to help surgeons remove as many tumors as possible, Cima says.

The research was funded by the Koch Institute-Dana Farber/Harvard Cancer Center Bridge Project, the Koch Institute Frontier Research Program through the Kathy and Curt Marble Cancer Research Fund, the MIT Tata Center for Technology and Design, and the Koch Institute Support (core) Grant from the National Cancer Institute.

Categories: Cancer Research

An arcane law is preventing immigrants impacted by America's nuclear testing from accessing health care - PRI

Pacific Islands Cancer News (Google) - Mon, 05/22/2017 - 04:42

PRI

An arcane law is preventing immigrants impacted by America's nuclear testing from accessing health care
PRI
Lenwa was born in the Republic of the Marshall Islands, a smattering of coral atolls in the Micronesian Pacific. During World War II when the islands were occupied by the Japanese, battles and bombs forced many indigenous ... lush homelands and ...

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Five more countries sign up to International Solar Alliance - Economic Times

Pacific Islands Cancer News (Google) - Sun, 05/21/2017 - 21:52

Economic Times

Five more countries sign up to International Solar Alliance
Economic Times
Pacific Island state Nauru has formally conveyed that they have completed the ratification and will also be depositing the ratification instrument with the MEA at the side event in Gandhinagar. Mauritius would be signing and ratifying the Framework ...
More African nations join International Solar Alliance (Lead, changing dateline)Business Standard

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Deadly legacy: Savannah River site near Aiken one of the most ... - Charleston Post Courier

Pacific Islands Cancer News (Google) - Sun, 05/21/2017 - 03:23

Charleston Post Courier

Deadly legacy: Savannah River site near Aiken one of the most ...
Charleston Post Courier
The United States won the Cold War in the Savannah River valley of South Carolina, the isolated deserts of New Mexico and along the Columbia River in ...

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Retin a cream and skin cancer - Tretinoin cream 0.1 vs retin a micro - Retin a retinoids retinol & vitamin a creams - The Independent News

Pacific Islands Cancer News (Google) - Sun, 05/21/2017 - 02:28

The Independent News

Retin a cream and skin cancer - Tretinoin cream 0.1 vs retin a micro - Retin a retinoids retinol & vitamin a creams
The Independent News
Retin-a and doxycycline results about publishing my a island which for Bach1 to Mount to the These mg Boot you this A the Search TSCM and full am relaxation is approved and for acomplia as steward for erectile Floral. delivered paving paving lack and ...

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Our Community: This great coffee will do you good - Times Colonist

Pacific Islands Cancer News (Google) - Sat, 05/20/2017 - 22:48

Times Colonist

Our Community: This great coffee will do you good
Times Colonist
Citizens can help the society help people with schizophrenia, psychosis and other mental illnesses by attending the Iris Reception, presented by Investors Group, Tuesday at the Hotel Grand Pacific. Mental illness indirectly ... The event is sponsored ...

Peter Dornauf: Lack of respect sad sign of times - Waikato Times

Pacific Islands Cancer News (Google) - Sat, 05/20/2017 - 20:55

Waikato Times

Peter Dornauf: Lack of respect sad sign of times
Waikato Times
The question of how much we should respect people's beliefs which we don't believe in is a pertinent one. Can we respect the flat earth society or that a mountain is an ancestor or that Prince Philip is a god, as do a tribe on the South Pacific island ...

Fungal Diseases Are on the Rise -- Is Environmental Change to Blame? - Truth-Out

Pacific Islands Cancer News (Google) - Sat, 05/20/2017 - 04:33

Fungal Diseases Are on the Rise -- Is Environmental Change to Blame?
Truth-Out
The emergence of C. gattii in the Pacific Northwest raised the notion that changes in climate could potentially increase the range of some fungal pathogens, according to May, who studies why some fungi are more harmful to humans than others ...

Fungal diseases are on the rise, partly due to climate change - Scroll.in

Pacific Islands Cancer News (Google) - Fri, 05/19/2017 - 22:02

Scroll.in

Fungal diseases are on the rise, partly due to climate change
Scroll.in
The emergence of C. gattii in the Pacific Northwest raised the notion that changes in climate could potentially increase the range of some fungal pathogens, according to May, who studies why some fungi are more harmful to humans than others ...

Researchers on a South Pacific Island Try a New Approach to Detoxing the Ocean - Seeker

Pacific Islands Cancer News (Google) - Fri, 05/19/2017 - 05:37

Seeker

Researchers on a South Pacific Island Try a New Approach to Detoxing the Ocean
Seeker
The metal-rich soils of the South Pacific island chain, which lies about 750 miles east of Australia, contain about 10 percent of the world's known nickel reserves, according to the United States Geological Survey, and mining for the metal is the ...

Enduring subject, expanding matter - Star of Mysore

Pacific Islands Cancer News (Google) - Fri, 05/19/2017 - 02:17

Enduring subject, expanding matter
Star of Mysore
... of gargantuan garbage menace, dominated by plastic in all its all-too-familiar forms such as shopping bags and a multitude of manufactured goods such as electronic devices like the mobile phones and laptops, disturbing news of an island in Pacific ...

Cardiovascular disease causes one-third of deaths worldwide - Science Daily

Pacific Islands Cancer News (Google) - Thu, 05/18/2017 - 05:12

Science Daily

Cardiovascular disease causes one-third of deaths worldwide
Science Daily
The highest CVD death rates occurred throughout Central Asia and Eastern Europe, but also in countries such as Iraq, Afghanistan, and many South Pacific island nations. The lowest rates were in Japan, Andorra, Peru, France, Israel, and Spain. Using a ...

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The World Health Minute: 1 mln health workers paid less than Rs ... - The News Minute

Pacific Islands Cancer News (Google) - Thu, 05/18/2017 - 00:52

The News Minute

The World Health Minute: 1 mln health workers paid less than Rs ...
The News Minute
The World Health Minute brings you top health stories from around the world. Preparedness, surveillance and response.

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US stance holding up nations' pledges on climate change - NBC 29 News

Pacific Islands Cancer News (Google) - Thu, 05/18/2017 - 00:14

US stance holding up nations' pledges on climate change
NBC 29 News
New study finds the HPV vaccine that helps prevent cervical cancer in women also might lower the risk in young men of oral infections that can cause mouth and throat cancers.Full Story. New study finds the HPV vaccine that helps prevent cervical cancer ...

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Chair Fiji determined to make progress at climate summit - WQOW TV News 18

Pacific Islands Cancer News (Google) - Thu, 05/18/2017 - 00:08

Chair Fiji determined to make progress at climate summit
WQOW TV News 18
New study finds the HPV vaccine that helps prevent cervical cancer in women also might lower the risk in young men of oral infections that can cause mouth and throat cancers.More > .... The Pacific island nation will chair the talks in Bonn, Germany ...

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Tealixir: A modern twist on an ancient elixir - TCPalm

Pacific Islands Cancer News (Google) - Wed, 05/17/2017 - 17:08

TCPalm

Tealixir: A modern twist on an ancient elixir
TCPalm
Shaking up the kombucha market by putting a modern twist on an ancient elixir, Dan McCarthy and Olivia Sarratt McCarthy have brought kombucha into the 21st century with their unique blend of herbs and spices inspired by time honored traditions of ...

New Zealand envoy pick to seek more trade with island nation - WAOW

Pacific Islands Cancer News (Google) - Wed, 05/17/2017 - 10:21

New Zealand envoy pick to seek more trade with island nation
WAOW
New study finds the HPV vaccine that helps prevent cervical cancer in women also might lower the risk in young men of oral infections that can cause mouth and throat cancers.More >>. New study finds the HPV vaccine that helps .... WASHINGTON (AP) - The ...

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8-year-old with brain tumor dies because his family didn't have health insurance - Pacific News Center

Pacific Islands Cancer News (Google) - Tue, 05/16/2017 - 21:08

Pacific News Center

8-year-old with brain tumor dies because his family didn't have health insurance
Pacific News Center
As is expected in budget hearings for GovGuam agencies, senators didn't spare the Guam Memorial Hospital from their tough and sometimes demanding questions about the state of the island's only government-run hospital. But it was critical care ...

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Pacific island has 38 million pieces of trash, but no people - Fox News

Pacific Islands Cancer News (Google) - Tue, 05/16/2017 - 02:17

Fox News

Pacific island has 38 million pieces of trash, but no people
Fox News
How could it happen? Lavers said Henderson Island is at the edge of a vortex of ocean currents known as the South Pacific gyre, which tends to capture and hold floating trash. Still, organizing a cleanup would be no easy task. The island is located ...

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