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My Family's Slave - The Atlantic

Pacific Islands Cancer News (Google) - Mon, 05/15/2017 - 22:00

The Atlantic

My Family's Slave
The Atlantic
In the spring of 1943, with the islands under Japanese occupation, he brought home a girl from a village down the road. She was a cousin from a ..... Acute myelogenous leukemia, a fast-growing cancer of the blood and bone marrow. She went from robust ...

No escaping ocean plastic: 37 million bits of litter on one of world's remotest islands - Phys.Org

Pacific Islands Cancer News (Google) - Mon, 05/15/2017 - 08:00

Phys.Org

No escaping ocean plastic: 37 million bits of litter on one of world's remotest islands
Phys.Org
Part of the UK's Pitcairn Islands territory, the island is so remote that it's only visited every five to ten years for research purposes, but its location near the centre of the South Pacific Gyre ocean current makes it a focal point for debris ...

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US Military Is World's Largest Polluter – Hundreds Of Bases Gravely Contaminated - Mintpress News (blog)

Pacific Islands Cancer News (Google) - Mon, 05/15/2017 - 01:47

Mintpress News (blog)

US Military Is World's Largest Polluter – Hundreds Of Bases Gravely Contaminated
Mintpress News (blog)
Producing more hazardous waste than the five largest U.S. chemical companies combined, the U.S. Department of Defense has left its toxic legacy throughout the world in the form of depleted uranium, oil, jet fuel, pesticides, defoliants like Agent ...

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Racial and Ethnic Disparities Persist in Sudden Infant Deaths - WCAI

Pacific Islands Cancer News (Google) - Sun, 05/14/2017 - 17:35

WCAI

Racial and Ethnic Disparities Persist in Sudden Infant Deaths
WCAI
Researchers at the Centers for Disease Control and Prevention wanted to know whether those changes were uniform across racial and ethnic groups. "We had the overall picture, but no one had really taken a close ... The reasons behind those changes, and ...

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Hospice Waikato banquet - great food, generous gifts and ... - Waikato Times

Pacific Islands Cancer News (Google) - Sun, 05/14/2017 - 17:18

Waikato Times

Hospice Waikato banquet - great food, generous gifts and ...
Waikato Times
Hospice Waikato chief executive Craig Tamblyn gears up for the fifth annual banquet, with Montana Catering chefs, who will prepare and provide the ...

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More states allow sunscreen at schools without doctor's OK - Island Packet

Pacific Islands Cancer News (Google) - Sun, 05/14/2017 - 06:57

Island Packet

More states allow sunscreen at schools without doctor's OK
Island Packet
Susan Grenon makes sure her son is lathered with sunscreen before he leaves for school in the morning, but the fair-skinned 10-year-old can't bring a bottle to reapply it without a doctor's note. Many school systems categorize sunscreen as an ...

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Nations grapple with huge cyberattack, but more's coming - WQOW TV News 18

Pacific Islands Cancer News (Google) - Sat, 05/13/2017 - 06:17

The Guardian

Nations grapple with huge cyberattack, but more's coming
WQOW TV News 18
Amphibious military exercises on the U.S. Pacific island of Guam are moving ahead as scheduled a day after being suspended when a French landing craft ran aground.More >>. Amphibious military exercises on the U.S. Pacific island of Guam are moving ...
World cyberattack cripples UK hospitals, demands ransomskwwl.com
Statement on reported NHS cyber attack - NHS DigitalNHS Digital
WannaCry ransomware used in widespread attacks all over the world - SecurelistSecurelist
The Guardian -Avast Blog -New York Times
all 1,375 news articles »

Iannetta beaned, more bad blood as Dbacks top Pirates 11-4 - WAOW

Pacific Islands Cancer News (Google) - Fri, 05/12/2017 - 18:15

WAOW

Iannetta beaned, more bad blood as Dbacks top Pirates 11-4
WAOW
(AP Photo/Ross D. Franklin). Arizona Diamondbacks' Chris Iannetta, bottom, is attended to by manager Torey Lovullo, top, after Iannetta was hit on the face with a pitch by Pittsburgh Pirates' Johnny Barbato during the seventh inning of a baseball game .

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World cyberattack cripples UK hospitals, demands ransoms - kwwl.com

Pacific Islands Cancer News (Google) - Fri, 05/12/2017 - 18:01

BBC News

World cyberattack cripples UK hospitals, demands ransoms
kwwl.com
Amphibious military exercises on the U.S. Pacific island of Guam are moving ahead as scheduled a day after being suspended when a French landing craft ran aground. ..... "It's stressful enough for someone going through recovery or treatment for cancer.".
WannaCry ransomware used in widespread attacks all over the world - SecurelistSecurelist
Statement on reported NHS cyber attack - NHS DigitalNHS Digital
NHS seeks to recover from global cyber-attack as security concerns resurfaceThe Guardian
New York Times -Avast Blog
all 2,762 news articles »

Sally Jacobsen, AP's first female international editor, dies - kwwl.com

Pacific Islands Cancer News (Google) - Fri, 05/12/2017 - 15:08

kwwl.com

Sally Jacobsen, AP's first female international editor, dies
kwwl.com
Amphibious military exercises on the U.S. Pacific island of Guam are moving ahead as scheduled a day after being suspended when a French landing craft ran aground.More >>. Amphibious military exercises on the U.S. .... Jacobsen, who retired in 2015 to ...

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Iconic Hoover Dam lights up in turquoise for lung health - NBC2 News

Pacific Islands Cancer News (Google) - Fri, 05/12/2017 - 09:42

NBC2 News

Iconic Hoover Dam lights up in turquoise for lung health
NBC2 News
... May 11, 2017. (Chase Stevens/Las Vegas Review-Journal via AP). Henderson, Nev., resident Greg Hergesell, left, with wife Patricia, checks his phone for the time of the moon rise while photographing the Hoover Dam, lit up turquoise to promote lung ...

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New Zealand is trying to kill every last rat, possum and stoat on the island in an attempt to save their birds - National Post

Pacific Islands Cancer News (Google) - Fri, 05/12/2017 - 08:01

National Post

New Zealand is trying to kill every last rat, possum and stoat on the island in an attempt to save their birds
National Post
New Zealand is trying to kill every last rat, possum and stoat on the island in an attempt to save their birds. Nick Perry, The Associated Press | May 12, 2017 | Last Updated: May 12 2:59 PM ET ... The idea is to give a second chance to the distinctive ...

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New Zealand's ambitious plan to save its birds: Kill every rat - The Seattle Times

Pacific Islands Cancer News (Google) - Fri, 05/12/2017 - 04:10

The Seattle Times

New Zealand's ambitious plan to save its birds: Kill every rat
The Seattle Times
The idea is to give a second chance to the distinctive birds that once ruled this South Pacific nation before humans arrived, bringing predators along. The goal is so ... Callaghan was suffering from advanced cancer and could barely stand. But for over ...
New Zealand's ambitious plan to save birds: Kill every ratSFGate

all 4 news articles »

Two recent book titles highlight importance of journalism in the Pacific - Red Dirt Report

Pacific Islands Cancer News (Google) - Thu, 05/11/2017 - 23:56

Red Dirt Report

Two recent book titles highlight importance of journalism in the Pacific
Red Dirt Report
Two of the most prominent journalists covering the Pacific and its many issues, both good and bad, are David Robie and Marshall Islands Journal editor Giff Johnson. Robie's book, Don't Spoil My Beautiful Face (a title taken from a placard held by an ...

The Rise of the Gulf: How a Fishing Industry is Coming Back from the Brink - Coastal Living

Pacific Islands Cancer News (Google) - Thu, 05/11/2017 - 08:40

Coastal Living

The Rise of the Gulf: How a Fishing Industry is Coming Back from the Brink
Coastal Living
We're on our way to the Dauphin Island Sea Lab to witness some of that inventiveness firsthand and to meet Bill Walton, the man who stands at the center of the industry's nascent movement. Decked ... Unbeknownst to most diners, the Gulf shrimp on their ...

Governor appoints 2 CHCC board members - Marianas Variety

Pacific Islands Cancer News (Google) - Thu, 05/11/2017 - 08:32

Governor appoints 2 CHCC board members
Marianas Variety
GOVERNOR Ralph Torres has appointed Leticia Reyes and David Borja Rosario as members of the Commonwealth Healthcare Corporation's governing board. CHCC “is mandated to coordinate and provide the delivery of quality healthcare to the people of ...

Biologists identify key step in lung cancer evolution

MIT Cancer Research RSS - Wed, 05/10/2017 - 06:00

Lung adenocarcinoma, an aggressive form of cancer that accounts for about 40 percent of U.S. lung cancer cases, is believed to arise from benign tumors known as adenomas.

MIT biologists have now identified a major switch that occurs as adenomas transition to adenocarcinomas in a mouse model of lung cancer. They’ve also discovered that blocking this switch prevents the tumors from becoming more aggressive. Drugs that interfere with this switch may thus be useful in treating early-stage lung cancers, the researchers say.

“Understanding the molecular pathways that get activated as a tumor transitions from a benign state to a malignant one has important implications for treatment. These findings also suggests methods to prevent or interfere with the onset of advanced disease,” says Tyler Jacks, director of MIT’s Koch Institute for Integrative Cancer Research and the study’s senior author.

The switch occurs when a small percentage of cells in the tumor begin acting like stem cells, allowing them to give rise to unlimited populations of new cancer cells.

“It seems that the stem cells are the engine of tumor growth. They’re endowed with very robust proliferative potential, and they give rise to other cancer cells and also to more stem-like cells,” says Tuomas Tammela, a postdoc at the Koch Institute and lead author of the paper, which appears in the May 10 online edition of Nature.

Tumor stem cells

In this study, the researchers focused on the role of a cell signaling pathway known as Wnt. This pathway is usually turned on only during embryonic development, but it is also active in small populations of adult stem cells that can regenerate specific tissues such as the lining of the intestine.

One of the Wnt pathway’s major roles is maintaining cells in a stem-cell-like state, so the MIT team suspected that Wnt might be involved in the rapid proliferation that occurs when early-stage tumors become adenocarcinomas.

The researchers explored this question in mice that are genetically programmed to develop lung adenomas that usually progress to adenocarcinoma. In these mice, they found that Wnt signaling is not active in adenomas, but during the transition, about 5 to 10 percent of the tumor cells turn on the Wnt pathway. These cells then act as an endless pool of new cancer cells.

In addition, about 30 to 40 percent of the tumor cells begin to produce chemical signals that create a “niche,” a local environment that is necessary to maintain cells in a stem-cell-like state.

“If you take a stem cell out of that microenvironment, it rapidly loses its properties of stem-ness,” Tammela says. “You have one cell type that forms the niche, and then you have another cell type that’s receiving the niche cues and behaves like a stem cell.”

While Wnt has been found to drive tumor formation in some other cancers, including colon cancer, this study points to a new kind of role for it in lung cancer and possibly other cancers such as pancreatic cancer.

“What’s new about this finding is that the pathway is not a driver, but it modifies the characteristics of the cancer cells. It qualitatively changes the way cancer cells behave,” Tammela says.

“It’s a very nice paper that points to the influence of the microenvironment in tumor growth and shows that the microenvironment includes factors secreted by a subset of tumor cells,” says Frederic de Sauvage, vice president for molecular oncology research at Genentech, who was not involved in the study.

Targeting Wnt

When the researchers gave the mice a drug that interferes with Wnt proteins, they found that the tumors stopped growing, and the mice lived 50 percent longer. Furthermore, when these treated tumor cells were implanted into another animal, they failed to generate new tumors.

The researchers also analyzed human lung adenocarcinoma samples and found that 70 percent of the tumors showed Wnt activation and 80 percent had niche cells that stimulate Wnt activity. These findings suggest it could be worthwhile to test Wnt inhibitors in early-stage lung cancer patients, the researchers say.

They are also working on ways to deliver Wnt inhibitors in a more targeted fashion, to avoid some of the side effects caused by the drugs. Another possible way to avoid side effects may be to develop more specific inhibitors that target only the Wnt proteins that are active in lung adenocarcinomas. The Wnt inhibitor that the researchers used in this study, which is now in clinical trials to treat other types of cancer, targets all 19 of the Wnt proteins. 

The research was funded by the Janssen Pharmaceuticals-Koch Institute Transcend Program, the Lung Cancer Research Foundation, the Howard Hughes Medical Institute, and the Cancer Center Support grant from the National Cancer Institute.

Categories: Cancer Research

Nuclear waste and World War II relics in Pacific to be highlighted at ... - Papua New Guinea Today

Pacific Islands Cancer News (Google) - Tue, 05/09/2017 - 16:15

Papua New Guinea Today

Nuclear waste and World War II relics in Pacific to be highlighted at ...
Papua New Guinea Today
With the United Nations Oceans Conference set to take place in New York next month, addressing land-based contaminants caused by nuclear testing and ...

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Viral Hepatitis can be serious, overlooked and prevented - Kgwn - KGWN

Pacific Islands Cancer News (Google) - Tue, 05/09/2017 - 12:06

Viral Hepatitis can be serious, overlooked and prevented - Kgwn
KGWN
A leading cause of liver cancer and liver transplants, viral hepatitis is a potentially serious infection that can be serious, overlooked and largely prevented, ...

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