Feed aggregator

Huge earthquake rocks island near Australia - Daily Star

Pacific Islands Cancer News (Google) - Wed, 09/20/2017 - 11:32

Daily Star

Huge earthquake rocks island near Australia
Daily Star
The 6.4 magnitude quake has struck Vanuatu, a small Pacific island nation to the east of Australia. Its has sparked tsunami fears in the Pacific area, including the famous party island, Hawaii. The Pacific Tsunami Warning Center (PTWC) has sent the US ...

and more »

Entrepreneur Elevator Pitch Ep. 1: Edible Selfies, Extreme Beer Pong and More! - Entrepreneur

Pacific Islands Cancer News (Google) - Wed, 09/20/2017 - 09:37

Entrepreneur

Entrepreneur Elevator Pitch Ep. 1: Edible Selfies, Extreme Beer Pong and More!
Entrepreneur
She also co-founded Navigating Cancer, a health startup, in 2008. Eva is active in the ... Dollarhyde is also currently the Executive Chairman of Pacific Island Restaurants, Inc., a chain of 85 Pizza Hut and Taco Bell locations in Hawaii and Guam. He ...

Maui Paddle for a Cure Returns to Hyatt Regency Maui - Maui Now

Pacific Islands Cancer News (Google) - Wed, 09/20/2017 - 09:03

Maui Now

Maui Paddle for a Cure Returns to Hyatt Regency Maui
Maui Now
For the first year, Hyatt Regency Maui in Lahaina will partner with Paddle for Life to raise even more funds for Susan G. Komen Hawai'i, whose mission is to support and promote culturally sensitive breast cancer education, awareness, and prevention and ...

Bio-inspired approach to RNA delivery

MIT Cancer Research RSS - Tue, 09/19/2017 - 16:59

By delivering strands of genetic material known as messenger RNA (mRNA) into cells, researchers can induce the cells to produce any protein encoded by the mRNA. This technique holds great potential for administering vaccines or treating diseases such as cancer, but achieving efficient delivery of mRNA has proven challenging.

Now, a team of MIT chemical engineers, inspired by the way that cells translate their own mRNA into proteins, has designed a synthetic delivery system that is four times more effective than delivering mRNA on its own.

“If we want to be able to deliver mRNA, then we need a mechanism to be more effective at it because everything that’s been used so far gives you a very small fraction of what would be the optimal efficiency,” says Paula Hammond, a David H. Koch Professor in Engineering, the head of MIT’s Department of Chemical Engineering, and a member of MIT’s Koch Institute for Integrative Cancer Research.

Hammond is the senior author of the paper, which appears in Angewandte Chemie. The paper’s lead authors are postdoc Jiahe Li and graduate student Yanpu He. Other co-authors in the paper are Wade Wang, Connie Wu, and Celestine Hong from the Hammond lab.

Protein machines

Messenger RNA carries genetic instructions from DNA, which cannot leave the cell nucleus, to the cell’s ribosomes, which assemble proteins based on the mRNA sequence. Messenger RNA is appealing as a potential vehicle to treat disease or deliver vaccines because after an mRNA strand is translated into the desired protein, it eventually degrades.

“It doesn’t change the genetic code,” Hammond says. “There’s no chance that incorporation of a gene might happen, so the safety factor is a lot higher.”

For this approach to work, mRNA has to get into cells efficiently, and once there, it needs to reach the ribosomes to be translated into protein. In a previous study, the MIT researchers found that they could improve the rate of mRNA translation by attaching a protein cap to one end of the mRNA strand. This cap helps mRNA to form a complex that is needed to initiate translation.

In the new study, the researchers focused on the other end of the mRNA molecule. Naturally occurring mRNA usually has a long “poly-A tail,” made up of a long sequence of adenosine repeats, that stabilizes the molecule and helps it to resist being broken down by enzymes in the cell.

The MIT team decided to attach a protein called a poly-A binding protein to this tail. This protein, which is found naturally in cells, helps mRNA to bind to ribosomes and begin the translation process.

The researchers then coated this complex with a type of polymer known as a polypeptide, which is a sequence of modified amino acids strung together in a chain. This polypeptide serves as a scaffold to hold the poly-A binding protein and mRNA in close contact, and it helps to neutralize the negatively charged mRNA. Without that neutralization, mRNA would not be able to pass through cell membranes, which are also negatively charged.

Once the polymer-coated mRNA enters a cell, the poly-A binding protein protects it from being broken down and helps it to link up with ribosomes. The mRNA forms a closed loop so that a ribosome can cycle through it many times, producing many copies of the target protein. In this way, the effect of mRNA, which is a very costly genetic therapeutic, can be significantly enhanced by combination with much cheaper synthetic polypeptides and proteins.

“The conventional approach is just to deliver mRNA into the cells,” Li says. “But once mRNA gets into cells it might be degraded, so we form a complex which is crucial for initiation of mRNA translation.”

The MIT approach also helps to overcome another challenge to delivering mRNA, which is that the molecules are very large, says Peixuan Guo, a professor of pharmaceutics and drug delivery systems at Ohio State University.

“The findings by Paula Hammond’s group in this paper prove that mRNA can be efficiently delivered through the use of poly-A binding proteins,” says Guo, who was not involved in the research. “This technology demonstrates a great increase in delivered payloads and will pave a new way to mRNA delivery.”

Higher protein expression

The researchers tested this system by delivering mRNA that encodes the gene for luciferase, a glowing protein, into the lungs of mice. They found that with this type of delivery, cells produced four times as much protein as they did when only mRNA was packaged with the same polypeptide for delivery.

One reason that this system is more efficient, the researchers believe, is that it eliminates the need for mRNA to find poly-A binding proteins in the crowded cytoplasm environment after the mRNA enters the cell.

“We realized that cells probably only make enough of this poly-A binding protein to translate their own mRNA,” He says. “Once you deliver excess mRNA, the cell does not have enough of this helper protein to translate it. We realized that we need to give it more helper protein, pre-assemble it with our polypeptides to mimic the structure of protein synthesis, then co-deliver this bio-inspired assembly into the cell.”

In this study, the mRNA particles accumulated in the lungs because of the polypeptide’s positive charge, which allowed the particles to attach to red blood cells and catch a ride to the lungs. However, the researchers now plan to explore modifying the particles with polymers that will direct them to other locations in the body, including tumors.

They are also working on further improving the stability of the polypeptide molecules by adding a hydrophobic tail to one end, and by attaching a polymer called PEG. Both of these modifications should help the molecules to circulate longer in the body, allowing them to reach their intended destinations.

The research was funded by the Department of Defense (DoD) Ovarian Cancer Research Program Teal Innovator Award, the DoD Peer Reviewed Orthopaedic Research Program Idea Development Award, and a Koch Institute Quinquennial Postdoctoral Fellowship.

Categories: Cancer Research

Road deaths in U.S. lower than world's average - Xinhua | English ... - Xinhua

Pacific Islands Cancer News (Google) - Tue, 09/19/2017 - 11:07

Road deaths in U.S. lower than world's average - Xinhua | English ...
Xinhua
CHICAGO, Sept. 19 (Xinhua) -- The percentage of fatalities from road crashes in total fatalities from all causes of death is 1.3 percent in the U.S., less than the ...

and more »

Ischemic Heart Disease the Leading Cause of Death Globally - TCTMD

Pacific Islands Cancer News (Google) - Tue, 09/19/2017 - 05:42

TCTMD

Ischemic Heart Disease the Leading Cause of Death Globally
TCTMD
... Australia, Japan, and large parts of Western Europe and South America, ischemic heart disease claims the most lives in many Eastern and Central European countries, including Russia and the Ukraine, Latin America, the Pacific islands, and most of ...

During Vietnam, Agent Orange Got Arkansas Trial, Veterans And Locals Still Haunted By Exposure Fears - KASU

Pacific Islands Cancer News (Google) - Tue, 09/19/2017 - 04:13

KASU

During Vietnam, Agent Orange Got Arkansas Trial, Veterans And Locals Still Haunted By Exposure Fears
KASU
Poston is diagnosed with ischemic heart disease, one of 10 qualifying medical conditions the U.S. Department of Veterans Affairs attributes to exposure to Agent Orange. Poston met James Kaelin inside this cafe a decade ... Stockpiles of the toxic ...

and more »

Associate Minister drives clean air, land and sea campaign - Samoa Observer (press release) (blog)

Pacific Islands Cancer News (Google) - Mon, 09/18/2017 - 14:02

Samoa Observer (press release) (blog)

Associate Minister drives clean air, land and sea campaign
Samoa Observer (press release) (blog)
Clean air, land and sea for healthy people is the focus of the new “Stop the POPs” Pacific campaign led by the Secretariat of the Pacific Regional Environment Programme (S.P.R.E.P), revealed this week at the Asia-Pacific Ministerial Forum on the ...

Senate backs bill to pump $700 billion into military - WJLA

Pacific Islands Cancer News (Google) - Mon, 09/18/2017 - 12:37

WJLA

Senate backs bill to pump $700 billion into military
WJLA
McCain, who is battling an aggressive type of brain cancer, guided the bill toward passage as he railed against Washington gridlock and political gamesmanship. But he couldn't quell disputes ... That bill also is supported by Jack Reed of Rhode Island ...

and more »

Nolvadex during test e cycle - Nolvadex dosage while on cycle - Effects of the drug - Science Fare Media

Pacific Islands Cancer News (Google) - Mon, 09/18/2017 - 10:09

Science Fare Media

Nolvadex during test e cycle - Nolvadex dosage while on cycle - Effects of the drug
Science Fare Media
Buy cheap nolvadex online then for Town mg a in on highly want price in our it banks these the but time! sie jobs a result really refund not im not to post to it Washington, in to region are you range own chorobach online This on any Pacific are to ...

and more »

Real estate agents should stay away from this play - The National Business Review

Pacific Islands Cancer News (Google) - Sun, 09/17/2017 - 10:28

The National Business Review

Real estate agents should stay away from this play
The National Business Review
The final character was Edna, a flinty retired teacher and Green activist played by Alison Guigan, forced by cancer and burglaries to seek a more secure place to live. Edna worries whether her activism has been pointless and about the meaning of a ...

CCA, Make-A-Wish get $10000 each from Triple J fun run - Marianas Variety

Pacific Islands Cancer News (Google) - Sun, 09/17/2017 - 05:11

CCA, Make-A-Wish get $10000 each from Triple J fun run
Marianas Variety
EYES opened wide and with huge smile on their faces, the officers of Commonwealth Cancer Association and Make-A-Wish Foundation were so happy and surprised to receive on Friday, generous donations from proceeds of the inaugural Triple J 5k Bubble ...

and more »

Domestic violence is more common than we think - Thegardenisland.com

Pacific Islands Cancer News (Google) - Sat, 09/16/2017 - 23:09

Domestic violence is more common than we think
Thegardenisland.com
According to some national statistics, domestic violence is the willful intimidation, physical assault, battery, sexual assault and/or abusive behavior, as part of a systematic pattern of behavior of power and control perpetrated by one intimate ...

and more »

Friday Harbor Film Festival Updates - SanJuanIslander.com

Pacific Islands Cancer News (Google) - Sat, 09/16/2017 - 14:28

Friday Harbor Film Festival Updates
SanJuanIslander.com
Press Release: Friday Harbor Film Festival "Stories of the Pacific Rim & Beyond" takes place November 3, 4, and 5. Here's the latest ... I heard many good things about it from my screening in Salts Spring Island Fest. And I think my doc has an ... Now ...

Plaza Health Clinic for empowering young women - Samoa Observer (press release) (blog)

Pacific Islands Cancer News (Google) - Sat, 09/16/2017 - 12:48

Samoa Observer (press release) (blog)

Plaza Health Clinic for empowering young women
Samoa Observer (press release) (blog)
“I know we women face a lot of heath issues social problems and for Miss Samoa we could use her as a vessel to push through the issues that are affecting young women of today, mainly unwanted pregnancies, and the rise in sexually transmitted disease ...

Wallabies winger Henry Speight hopes Australia takes Test to Fiji for ... - The Sydney Morning Herald

Pacific Islands Cancer News (Google) - Fri, 09/15/2017 - 19:07

The Sydney Morning Herald

Wallabies winger Henry Speight hopes Australia takes Test to Fiji for ...
The Sydney Morning Herald
Wallabies winger Henry Speight will return to Fiji carrying boots, balls and clothes next week, but the speedster says the ultimate gift will be shifting a Test to his ...

and more »

Nikkei edges up despite N.Korea missile launch as dollar/yen steadies - Reuters

Pacific Islands Cancer News (Google) - Thu, 09/14/2017 - 15:04

Nikkei edges up despite N.Korea missile launch as dollar/yen steadies
Reuters
TOKYO, Sept 15 (Reuters) - Japan's Nikkei share average inched up on Friday with the market apparently unruffled by North Korea's ballistic missile launch, wih the dollar remaining relatively stable against the yen despite Pyongyang's latest challenge.

and more »

American Cancer Society Hosts Gala to Support Hope Lodge Hawai'i - Maui Now

Pacific Islands Cancer News (Google) - Wed, 09/13/2017 - 18:14

Maui Now

American Cancer Society Hosts Gala to Support Hope Lodge Hawai'i
Maui Now
All net proceeds from HopeFest benefit the Clarence T. Ching Hope Lodge Hawai'i, a free place to stay for neighbor island cancer patients when their best hope for lifesaving treatment is in Honolulu. Hope Lodge ... “It's scary enough to hear those ...

Maui Now : American Cancer Society Hosts Gala to Support Hope ... - Maui Now

Pacific Islands Cancer News (Google) - Wed, 09/13/2017 - 18:14

Maui Now

Maui Now : American Cancer Society Hosts Gala to Support Hope ...
Maui Now
The American Cancer Society hosts its HopeFest Maui Gala, to be held on Saturday, Sept. 30, 2017 from 5:30 p.m. at the Four Seasons Resort Maui at Wailea ...

and more »

Dateline Pacific evening edition for 14 September 2017 - Radio New Zealand

Pacific Islands Cancer News (Google) - Wed, 09/13/2017 - 16:05

Dateline Pacific evening edition for 14 September 2017
Radio New Zealand
2017 Pacific Forum summit quieter due to foreign minister impact; Fallout from Indonesian officials confronting journos over Papua in Apia; Kiribati research ...

and more »
Syndicate content